Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients

Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients

HIV infection significantly increases TB susceptibility due to CD4 T-cell loss and macrophage dysfunction. Although it is relatively clear that CD4 T-cell loss represents a direct effect of HIV infection, the mechanism underlying how HIV infection dampens macrophage function is unknown. Here, we sho...

Full description

Bibliographic Details
Main Authors: Youchao Dai, Yi Cai, Xin Wang, Jialou Zhu, Xiaoqian Liu, Houming Liu, Linghua Li, Yinze Zhang, Shengze Liu, Zhihua Wen, Carl G. Feng, Xinchun Chen, Xiaoping Tang
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
hiv
erythrophagocytosis
heme oxygenase-1
autophagy
tuberculosis
Online Access:https://doi.org/10.1128/mBio.03246-19

Internet

https://doi.org/10.1128/mBio.03246-19

Similar Items