Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Abstract Objective Primary Sjögren syndrome (pSS) is characterized by T and B cell infiltration of exocrine glands. The cysteine protease cathepsin S (CatS) is crucially involved in MHCII processing and T cell stimulation, and elevated levels have been found in patients with RA, psoriasis and pSS. H...

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Bibliographic Details
Main Authors: Patrick Hargreaves, Douglas Daoudlarian, Michel Theron, Fabrice A. Kolb, Marianne Manchester Young, Bernhard Reis, Andre Tiaden, Bettina Bannert, Diego Kyburz, Tobias Manigold
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Arthritis Research & Therapy
Subjects:
Primary Sjögren syndrome
Cathepsin S
Tear fluid
T cell responses
RO5459072
Online Access:http://link.springer.com/article/10.1186/s13075-019-1955-2

Internet

http://link.springer.com/article/10.1186/s13075-019-1955-2

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