A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

Abstract Background Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of Parkinson’s disease. However, the function and molecular pathways regulated by LRRK2 are largely unknown. It has been shown...

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Bibliographic Details
Main Authors: Alena Salašová, Chika Yokota, David Potěšil, Zbyněk Zdráhal, Vítězslav Bryja, Ernest Arenas
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Neurodegeneration
Subjects:
WNT/planar cell polarity
PRICKLE1
CELSR1
DVL
Parkinson’s disease
Dopaminergic neurons
Online Access:http://link.springer.com/article/10.1186/s13024-017-0193-9

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http://link.springer.com/article/10.1186/s13024-017-0193-9

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