Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression.

Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression.

We recently identified Smads1, 5 and 8 as muscle biomarkers in human ALS. In the ALS mouse, these markers are elevated and track disease progression. Smads are signal transducers and become activated upon receptor engagement of ligands from the TGF-β superfamily. Here, we sought to characterize liga...

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Bibliographic Details
Main Authors: Ying Si, Soojin Kim, Xiangqin Cui, Lei Zheng, Shin J Oh, Tina Anderson, Mohammad AlSharabati, Mohamed Kazamel, Laura Volpicelli-Daley, Marcas M Bamman, Shaohua Yu, Peter H King
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4574401?pdf=render

Internet

http://europepmc.org/articles/PMC4574401?pdf=render

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