Immune-Deficient Pfp/Rag2<sup>−/−</sup> Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice

Immune-Deficient Pfp/Rag2<sup>−/−</sup> Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice

Aging is a risk factor for adipose tissue dysfunction, which is associated with inflammatory innate immune mechanisms. Since the adipose tissue/liver axis contributes to hepatosteatosis, we sought to determine age-related adipose tissue dysfunction in the context of the activation of the innate immu...

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Bibliographic Details
Main Authors: Sandra Winkler, Madlen Hempel, Mei-Ju Hsu, Martin Gericke, Hagen Kühne, Sandra Brückner, Silvio Erler, Ralph Burkhardt, Bruno Christ
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
hepatosteatosis
innate immune system
aging
liver
adipose tissue
hepatocyte
Online Access:https://www.mdpi.com/2073-4409/8/8/775

Internet

https://www.mdpi.com/2073-4409/8/8/775

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