Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-α-mediated neurotoxicity

HIV-1 infection causes, with increasing prevalence, neurological disorders characterized in part by neuronal cell death. The HIV-1 protein Tat has been shown to be directly and indirectly neurotoxic. Here, we tested the hypothesis that a non-neurotoxic epitope of Tat can, through actions on immune c...

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Bibliographic Details
Main Authors: Lara Buscemi, David Ramonet, Jonathan D. Geiger
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neurobiology of Disease
Subjects:
Tat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000617