Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review

Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review

Abstract Drug-induced liver injury (DILI) causes one in three market withdrawals due to adverse drug reactions, causing preventable human suffering and massive financial loss. We applied evidence-based methods to investigate the role of preclinical studies in predicting human DILI using two anti-dia...

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Bibliographic Details
Main Authors: Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, Jyotsna Mehta, Seneca E. Fitch, Pandora Pound, Rebecca Ram, Breanne Kincaid, Cathalijn H. C. Leenaars, Minjun Chen, Robert A. Wright, Katya Tsaioun
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85708-2

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https://doi.org/10.1038/s41598-021-85708-2

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