Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo

Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo

TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To further understand the role of TDP-43 in mRNA/protein metabolism and proteostasis, we used a combined approach with cellular and...

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Bibliographic Details
Main Authors: Santiago E. Charif, Luciana Luchelli, Antonella Vila, Matías Blaustein, Lionel M. Igaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
TDP-43
frontotemporal dementia (FTD)
amyotrophic lateral sclerosis (ALS)
transgenic mice
protein synthesis
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.594561/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.594561/full

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