Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia

Objective: Chronic hypoxia induces pulmonary and cardiovascular pathologies, including pulmonary hypertension (PH). L-arginine:glycine amidinotransferase (AGAT) is essential for homoarginine (hArg) and guanidinoacetate synthesis, the latter being converted to creatine by guanidinoacetate methyltrans...

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Bibliographic Details
Main Authors: Juliane Hannemann, Kathrin Cordts, Anika Seniuk, Chi-un Choe, Lena Schmidt-Hutten, Jorge Duque Escobar, Florian Weinberger, Rainer Böger, Edzard Schwedhelm
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
creatine
homoarginine
hypoxia
L-arginine:glycine amidinotransferase
pulmonary hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.703069/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.703069/full

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