Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1).

Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1).

Heparanase is an enzyme involved in extracellular matrix remodelling and heparan sulphate proteoglycan catabolism. It is secreted by metastatic tumour cells, allowing them to penetrate the endothelial cell layer and basement membrane to invade target organs. The release of growth factors at the site...

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Bibliographic Details
Main Authors: Suzanne C Simmons, Edward A McKenzie, Lynda K Harris, John D Aplin, Paul E Brenchley, Maria N Velasco-Garcia, Sotiris Missailidis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22719856/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22719856/?tool=EBI

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