Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients

Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients

Vast transcriptomics and epigenomics changes are characteristic of human cancers, including leukaemia. At remission, we assume that these changes normalise so that omics-profiles resemble those of healthy individuals. However, an in-depth transcriptomic and epigenomic analysis of cancer remission ha...

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Bibliographic Details
Main Authors: Ulf Schmitz, Jaynish S. Shah, Bijay P. Dhungel, Geoffray Monteuuis, Phuc-Loi Luu, Veronika Petrova, Cynthia Metierre, Shalima S. Nair, Charles G. Bailey, Verity A. Saunders, Ali G. Turhan, Deborah L. White, Susan Branford, Susan J. Clark, Timothy P. Hughes, Justin J.-L. Wong, John E.J. Rasko
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
transcriptomic complexity
alternative splicing
intron retention
DNA methylation
epigenetics
BCR-ABL1
Online Access:https://www.mdpi.com/2072-6694/12/12/3738

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https://www.mdpi.com/2072-6694/12/12/3738

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