Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

Abstract Background Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases remains not well established, and few studies have confirmed their molecul...

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Bibliographic Details
Main Authors: Haiquan Li, Jungwei Fan, Francesca Vitali, Joanne Berghout, Dillon Aberasturi, Jianrong Li, Liam Wilson, Wesley Chiu, Minsu Pumarejo, Jiali Han, Colleen Kenost, Pradeep C. Koripella, Nima Pouladi, Dean Billheimer, Edward J. Bedrick, Yves A. Lussier
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Medical Genomics
Subjects:
Disease comorbidities
GWAS studies
eQTL
Genetic network
Non-coding variants
RNA
Online Access:http://link.springer.com/article/10.1186/s12920-018-0428-9

Internet

http://link.springer.com/article/10.1186/s12920-018-0428-9

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