Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to dissect lineage-specific WDR62 function(s). Interesting...

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Bibliographic Details
Main Authors: Nicholas R. Lim, Belal Shohayeb, Olga Zaytseva, Naomi Mitchell, S. Sean Millard, Dominic C.H. Ng, Leonie M. Quinn
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
neuroblast
glia
WD-repeat protein
WDR62
AURKA
mitosis
Drosophila
brain
microcephaly
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302229

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http://www.sciencedirect.com/science/article/pii/S2213671117302229

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