Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

During transcription elongation, RNA polymerase has been assumed to attain equilibrium between pre- and post-translocated states rapidly relative to the subsequent catalysis. Under this assumption, recent single-molecule studies proposed a branched Brownian ratchet mechanism that necessitates a puta...

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Bibliographic Details
Main Authors: Manchuta Dangkulwanich, Toyotaka Ishibashi, Shixin Liu, Maria L Kireeva, Lucyna Lubkowska, Mikhail Kashlev, Carlos J Bustamante
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-09-01
Series:eLife
Subjects:
RNA polymerase II
transcription elongation
Brownian ratchet
translocation
backtracking
optical tweezer
Online Access:https://elifesciences.org/articles/00971

Internet

https://elifesciences.org/articles/00971

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