Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.

Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.

Gastrointestinal barrier immaturity predisposes preterm infants to necrotizing enterocolitis (NEC). Intraepithelial lymphocytes (IEL) bearing the unconventional T cell receptor (TCR) γδ (γδ IEL) maintain intestinal integrity and prevent bacterial translocation in part through production of interleuk...

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Bibliographic Details
Main Authors: Jörn-Hendrik Weitkamp, Michael J Rosen, Zhiguo Zhao, Tatsuki Koyama, Duke Geem, Timothy L Denning, Michael T Rock, Daniel J Moore, Melissa D Halpern, Pranathi Matta, Patricia W Denning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4048281?pdf=render

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http://europepmc.org/articles/PMC4048281?pdf=render

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