Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery.

Sleep loss causes profound cognitive impairments and increases the concentrations of adenosine and adenosine A1 receptors in specific regions of the brain. Time courses for performance impairment and recovery differ between acute and chronic sleep loss, but the physiological basis for these time cou...

Full description

Bibliographic Details
Main Authors: Andrew J K Phillips, Elizabeth B Klerman, James P Butler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5675465?pdf=render