Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice

Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice

The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy kynurenine and quinolinic acid, which are involved in the neurodegenerative mechanisms that underlie Alzheimer’s disease (AD). Indolamine 2,3-diox...

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Bibliographic Details
Main Authors: Emre Fertan, Kurt R.J. Stover, Michael G. Brant, Paul M. Stafford, Brendan Kelly, Elena Diez-Cecilia, Aimée A. Wong, Donald F. Weaver, Richard E. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
kynurenine pathway
quinolinic acid
behavior
mouse models
novel therapeutic
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01044/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01044/full

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