Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells.

Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells.

The androgen receptor (AR) is activated in patients with castration resistant prostate cancer (CRPC) despite low circulating levels of androgen, suggesting that intracellular signaling pathways and non-androgenic factors may contribute to AR activation. Many G-protein coupled receptors (GPCR) and th...

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Bibliographic Details
Main Authors: Julie Pratibha Singh, Manisha Dagar, Gunjan Dagar, Sudhir Kumar, Sudhir Rawal, Ravi Datta Sharma, Rakesh Kumar Tyagi, Gargi Bagchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226056

Internet

https://doi.org/10.1371/journal.pone.0226056

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