Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

To investigate the impact of mipomersen, an apolipoprotein B-100 (apoB) synthesis inhibitor, on intra-hepatic triglyceride content (IHTG content), we conducted a randomized, double-blind, placebo-controlled study in 21 patients with familial hypercholesterolemia (FH). Subjects received a weekly subc...

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Bibliographic Details
Main Authors: Maartje E. Visser, Fatima Akdim, Diane L. Tribble, Aart J. Nederveen, T. Jesse Kwoh, John J.P. Kastelein, Mieke D. Trip, Erik S.G. Stroes
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
antisense oligonucleotides
drug therapy
familial hypobetalipoproteinemia
hepatic steatosis
LDL-cholesterol
localized proton magnetic resonance spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410612

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http://www.sciencedirect.com/science/article/pii/S0022227520410612

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