Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of β<sub>2</sub>AR-cAMP Signalling

Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of β<sub>2</sub>AR-cAMP Signalling

The ability to differentiate induced-pluripotent stem cells into cardiomyocytes (iPSC-CMs) has opened up novel avenues for potential cardiac therapies. However, iPSC-CMs exhibit a range of somewhat immature functional properties. This study explored the development of the beta-adrenergic receptor (β...

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Bibliographic Details
Main Authors: Alveera Hasan, Neda Mohammadi, Aisha Nawaz, Thusharika Kodagoda, Ivan Diakonov, Sian E. Harding, Julia Gorelik
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
cAMP
β-adrenergic receptors
phosphodiesterase
caveolae
FRET
iPSC-cardiomyocytes
Online Access:https://www.mdpi.com/2073-4409/9/10/2275

Internet

https://www.mdpi.com/2073-4409/9/10/2275

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