Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice.

Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice.

Loss of Parkin, encoded by PARK2 gene, is a major cause of autosomal recessive Parkinson's disease. In Drosophila and mammalian cell models Parkin has been shown in to play a role in various processes essential to maintenance of mitochondrial quality, including mitochondrial dynamics, biogenesi...

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Bibliographic Details
Main Authors: Maria Damiano, Clément A Gautier, Anne-Laure Bulteau, Rosa Ferrando-Miguel, Caroline Gouarne, Marc Giraudon Paoli, Rebecca Pruss, Françoise Auchère, Caroline L'Hermitte-Stead, Frédéric Bouillaud, Alexis Brice, Olga Corti, Anne Lombès
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069072?pdf=render

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http://europepmc.org/articles/PMC4069072?pdf=render

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