Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice

Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice

Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunomodulatory function. To study the mechanism by which MDSC affect antimicrobial immunity, we infected mice with two M. avium strains of differential virulence, highly virulent Mycobacterium avium subsp. avium strain 25291 (...

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Bibliographic Details
Main Authors: Ketema Abdissa, Andreas Nerlich, Andreas Beineke, Nanthapon Ruangkiattikul, Vinay Pawar, Ulrike Heise, Nina Janze, Christine Falk, Dunja Bruder, Ulrike Schleicher, Christian Bogdan, Siegfried Weiss, Ralph Goethe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
MDSC
non-tuberculous mycobacteria
T cells
dendritic cells
iNOS
Nos2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02317/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02317/full

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