EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer.

EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer.

Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed in epithelial cancers and in retinoblastoma (RB). We fabricated an EpCAM targeting aptamer-siRNA chimera and investigated its anti-tumor property and EpCAM intracellular domain (EpICD) mediated signaling in...

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Bibliographic Details
Main Authors: Nithya Subramanian, Jagat R Kanwar, Rupinder K Kanwar, JagadeeshBabu Sreemanthula, Jyotirmay Biswas, Vikas Khetan, Subramanian Krishnakumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503753?pdf=render

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http://europepmc.org/articles/PMC4503753?pdf=render

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