Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is usually accompanied by phenotypic changes, analys...

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Bibliographic Details
Main Authors: Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Nicolás Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raúl Germán Spallanzani, Agustín Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
NK cells
renal cell carcinoma
CD85j
CD45
CD48
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.681615/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.681615/full

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