MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions

MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions

Although the genetic basis of mitral valve prolapse (MVP) has now been clearly established, the molecular and cellular mechanisms involved in the pathological processes associated to a specific mutation often remain to be determined. The FLNA gene (encoding Filamin A; FlnA) was the first gene associ...

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Bibliographic Details
Main Authors: Damien Duval, Pauline Labbé, Léa Bureau, Thierry Le Tourneau, Russell A. Norris, Roger R. Markwald, Robert Levine, Jean-Jacques Schott, Jean Mérot
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
Filamin-A
PTPN12
mitral valve prolapse
p190RhoGAP
Src
Online Access:http://www.mdpi.com/2308-3425/2/3/233

Internet

http://www.mdpi.com/2308-3425/2/3/233

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