Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

Neuropathic pain resulting from nerve injury can become persistent and difficult to treat but the molecular signaling responsible for its development remains poorly described. Here, we identify the neuronal stress sensor dual leucine zipper kinase (DLK; Map3k12) as a key molecule controlling the mal...

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Bibliographic Details
Main Authors: Josette J Wlaschin, Jacob M Gluski, Eileen Nguyen, Hanna Silberberg, James H Thompson, Alexander T Chesler, Claire E Le Pichon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
pain
microglia
somatosensation
mechanical allodynia
neuropathic
kinase
Online Access:https://elifesciences.org/articles/33910

Internet

https://elifesciences.org/articles/33910

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