Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked b...

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Bibliographic Details
Main Authors: Annie Mayence, Guangdi Wang, Jean J. Vanden Eynde, Nageswara Rao Kode, Tien L. Huang
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
prodrugs
amidoximes
oxadiazoles
Pneumocystis carinii
Trypanosoma brucei
Online Access:http://www.mdpi.com/1420-3049/18/9/11250

Internet

http://www.mdpi.com/1420-3049/18/9/11250

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