Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis.

Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis.

BACKGROUND: Regulatory T cells (Tregs) are highly prevalent in tumor tissue and can suppress effective anti-tumor immune responses. However, the source of the increased tumor-infiltrating Tregs and their contribution to cancer progression remain poorly understood. METHODOLOGY/PRINCIPAL FINDING: We h...

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Bibliographic Details
Main Authors: Kang-Jie Chen, Sheng-Zhang Lin, Lin Zhou, Hai-Yang Xie, Wu-Hua Zhou, Ahmed Taki-Eldin, Shu-Sen Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3173477?pdf=render

Internet

http://europepmc.org/articles/PMC3173477?pdf=render

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