CACNA1C Gene rs11832738 Polymorphism Influences Depression Severity by Modulating Spontaneous Activity in the Right Middle Frontal Gyrus in Patients With Major Depressive Disorder

CACNA1C Gene rs11832738 Polymorphism Influences Depression Severity by Modulating Spontaneous Activity in the Right Middle Frontal Gyrus in Patients With Major Depressive Disorder

ObjectivesThis study aimed to examine whether the CACNA1C gene rs11832738 polymorphism and major depressive disorder (MDD) have an interactive effect on the untreated regional amplitude of low-frequency fluctuation (ALFF) and to determine whether regional ALFF mediates the association between CACNA1...

Full description

Bibliographic Details
Main Authors: Xiaoyun Liu, Zhenghua Hou, Yingying Yin, Chunming Xie, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Yonggui Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder (MDD)
amplitude of low-frequency fluctuation (ALFF)
right medial frontal gyrus (MFG)
mediation effect
depression severity
CACNA1C
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00073/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2020.00073/full

Similar Items