Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome

NLR family pyrin domain containing 3 (NLRP3) inflammasome accompanies chronic liver injury and is a critical mediator of inflammation-driven liver fibrosis. Sphingosine 1-phosphate (S1P)/S1P Receptor (S1PR) signaling participates in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/...

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Bibliographic Details
Main Authors: Lei Hou, Le Yang, Na Chang, Xinhao Zhao, Xuan Zhou, Chengbin Dong, Fuquan Liu, Lin Yang, Liying Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
macrophage
NLR family pyrin domain-containing 3
inflammation
sphingosine 1-phosphate
S1P receptor 2
liver injury
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01149/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01149/full

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