Inhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6.

Inhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6.

Senescence and apoptosis are two distinct cellular programs that are activated in response to a variety of stresses. Low or high doses of the same stressor, i.e., the anticancer drug doxorubicin, may either induce apoptosis or senescence, respectively, in cardiac muscle cells. We have demonstrated t...

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Bibliographic Details
Main Authors: Paola Altieri, Paolo Spallarossa, Chiara Barisione, Silvano Garibaldi, Anna Garuti, Patrizia Fabbi, Giorgio Ghigliotti, Claudio Brunelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458009?pdf=render

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http://europepmc.org/articles/PMC3458009?pdf=render

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