Lectin-Like Transcript 1 (LLT1) Checkpoint: A Novel Independent Prognostic Factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma

Lectin-Like Transcript 1 (LLT1) Checkpoint: A Novel Independent Prognostic Factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma

Lectin-like transcript 1 (LLT1) expression by tumor cells contributes to immune evasion, thereby emerging as a natural killer (NK) cell-mediated immunotherapeutic target. This study is the first to investigate LLT1 expression (encoded by <i>CLEC2D</i> gene) in head and neck cancers to as...

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Bibliographic Details
Main Authors: Mario Sanchez-Canteli, Francisco Hermida-Prado, Christian Sordo-Bahamonde, Irene Montoro-Jiménez, Esperanza Pozo-Agundo, Eva Allonca, Aitana Vallina-Álvarez, César Álvarez-Marcos, Segundo Gonzalez, Juana M. García-Pedrero, Juan P. Rodrigo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomedicines
Subjects:
lectin-like transcript 1
LLT1
CLEC2D
immune checkpoint
NK cell
head and neck squamous cell carcinomas
Online Access:https://www.mdpi.com/2227-9059/8/12/535

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https://www.mdpi.com/2227-9059/8/12/535

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