Dual interleukin-17A/F deficiency protects against acute and chronic response to cigarette smoke exposure in mice

Dual interleukin-17A/F deficiency protects against acute and chronic response to cigarette smoke exposure in mice

Abstract IL-17A and IL-17F are both involved in the pathogenesis of neutrophilic inflammation observed in COPD and severe asthma. To explore this, mice deficient in both Il17a and Il17f and wild type (WT) mice were exposed to cigarette smoke or environmental air for 5 to 28 days and changes in infla...

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Main Authors: Hiroo Wada, Masuo Nakamura, Shin-Ichi Inoue, Akihiko Kudo, Tomoko Hanawa, Yoichiro Iwakura, Fumie Kobayashi, Hiroshi Kamma, Shigeru Kamiya, Kazuhiro Ito, Peter J. Barnes, Hajime Takizawa
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90853-9

Internet

https://doi.org/10.1038/s41598-021-90853-9

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