Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated immunity against invading pathogens. PRR ligands are frequently conjugated to tumor-associated antigens in a vaccination st...

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Bibliographic Details
Main Authors: Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. Bruijns, Tim Arnoldus, Corinne Vivès, Chung C. Wong, Michel Thépaut, Nico J. Meeuwenoord, Hans van den Elst, Herman S. Overkleeft, Gijs A. van der Marel, Dmitri V. Filippov, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Chemistry
Subjects:
DC-SIGN
TLR7
glyco-antigen
vaccine model
peptide conjugate
tumor-associated antigens
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00650/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00650/full

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