Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment

Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment

For cutaneous squamous cell carcinoma (cSCC), topical treatment is an essential option for patients who are not candidates for, or who refuse, surgery. Epidermal growth factor receptor (EGFR) plays a key role in the development of cSCC, but EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib,...

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Bibliographic Details
Main Authors: Jun Inoue, Kyoko Fujiwara, Hidetoshi Hamamoto, Katsunori Kobayashi, Johji Inazawa
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
miRNA therapeutics
skin cancer
EGFR-TKI
glutaminolysis
topical treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301601

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http://www.sciencedirect.com/science/article/pii/S2372770520301601

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