Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.

Bibliographic Details
Main Authors: Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09152-7

Internet

https://doi.org/10.1038/s41467-019-09152-7

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