Interplay Between Membrane Permeability and Enzymatic Barrier Leads to Antibiotic-Dependent Resistance in Klebsiella Pneumoniae

Interplay Between Membrane Permeability and Enzymatic Barrier Leads to Antibiotic-Dependent Resistance in Klebsiella Pneumoniae

The interplay between membrane permeability alterations and the enzymatic barrier contributes to Klebsiella pneumoniae multidrug resistance. We assessed the specific effect of the efflux levels of the main efflux pumps (AcrAB and OqxAB), alone and associated with the loss of the main porins (OmpK35...

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Bibliographic Details
Main Authors: Marie-Helene Nicolas-Chanoine, Noémie Mayer, Kathleen Guyot, Estelle Dumont, Jean-Marie Pagès
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
efflux pump
porins
beta-lactamases
resistance mechanism interplay
ceftolozane+tazobactam
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01422/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01422/full

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