E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

Abstract The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the signal peptide of E-cadherin without changing the remaining predicted sequence....

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Bibliographic Details
Main Authors: Joana Figueiredo, Soraia Melo, Kimberley Gamet, Tanis Godwin, Susana Seixas, João M. Sanches, Parry Guilford, Raquel Seruca
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
Hereditary Diffuse Gastric Cancer
E-cadherin
CDH1
Germline variants
Signal peptide
Post-translational mechanism
Online Access:http://link.springer.com/article/10.1186/s12943-018-0859-0

Internet

http://link.springer.com/article/10.1186/s12943-018-0859-0

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