Small Molecules Targeting H3K9 Methylation Prevent Silencing of Reactivated <i>FMR1</i> Alleles in Fragile X Syndrome Patient Derived Cells
In fragile X syndrome (FXS), expansion of a CGG repeat tract in the 5′-untranslated region of the <i>FMR1</i> gene to >200 repeats causes transcriptional silencing by inducing heterochromatin formation. Understanding the mechanism of <i>FMR1</i> silencing is important as g...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/11/4/356 |