PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life

PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life

PR domain-containing member 12 (PRDM12) is a key developmental transcription factor in sensory neuronal specification and survival. Patients with rare deleterious variants in PRDM12 are born with congenital insensitivity to pain (CIP) due to the complete absence of a subtype of peripheral neurons th...

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Bibliographic Details
Main Authors: Tomislav Kokotović, Michiel Langeslag, Ewelina M. Lenartowicz, John Manion, Christopher W. Fell, Elham Alehabib, Abbas Tafakhori, Hossein Darvish, Eric J. Bellefroid, G. Gregory Neely, Michaela Kress, Josef M. Penninger, Vanja Nagy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Prdm12
TRPV1
capsaicin
pain
nociception
CIP
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.720973/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.720973/full

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