Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.

Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.

BACKGROUND: Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity. Recently, we demonstrated that IL-17 produced during exp...

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Bibliographic Details
Main Authors: Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez, Grace Kelly Silva, Renata Dellalibera-Joviliano, Gerson Jhonatan Rodrigues, Lusiane Maria Bendhack, Anis Rassi, André Schmidt, Benedito Carlos Maciel, José Antonio Marin Neto, João Santana Silva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3335880?pdf=render

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http://europepmc.org/articles/PMC3335880?pdf=render

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