Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...

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Bibliographic Details
Main Authors: Stephen eToth, Ernst E Brueggemann, George A Oyler, Leonard A Smith, Harry B. Hines, S. Ashraf eAhmed
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Pharmacology
Subjects:
Botulinum neorotoxin
Tyrosine phosphorylation
Zinc endoporotease
Protease
Clhostridium botulinum
Protein phosphorylation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00102/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00102/full

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