Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth

Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth

Osteosarcoma (OS) and Ewing’s sarcoma (ES) are the most common malignant bone tumors in children and adolescents. In many cases, the prognosis remains very poor. The Sonic hedgehog (SHH) signaling pathway, strongly involved in the development of many cancers, regulate transcription via the transcrip...

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Bibliographic Details
Main Authors: Mathilde Mullard, Marie Cadé, Sarah Morice, Maryne Dupuy, Geoffroy Danieau, Jérome Amiaud, Sarah Renault, Frédéric Lézot, Régis Brion, Rose Anne Thepault, Benjamin Ory, François Lamoureux, Isabelle Corre, Bénédicte Brounais-LeRoyer, Françoise Rédini, Franck Verrecchia
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
SHH
Gli1
GANT61
ewing’s sarcoma
osteosarcoma
primary tumor growth
Online Access:https://www.mdpi.com/2072-6694/12/11/3438

Internet

https://www.mdpi.com/2072-6694/12/11/3438

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