Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activity in the caudal hindbrain of zebrafish.

Bibliographic Details
Main Authors: Matthew N. McCarroll, Leo Gendelev, Reid Kinser, Jack Taylor, Giancarlo Bruni, Douglas Myers-Turnbull, Cole Helsell, Amanda Carbajal, Capria Rinaldi, Hye Jin Kang, Jung Ho Gong, Jason K. Sello, Susumu Tomita, Randall T. Peterson, Michael J. Keiser, David Kokel
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11936-w

Internet

https://doi.org/10.1038/s41467-019-11936-w

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