ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

Abstract Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in inherited and sporadic ALS, indicating that dysfunction in TDP-43 is causative...

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Bibliographic Details
Main Authors: Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi, Koji Yamanaka
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Brain
Subjects:
Amyotrophic lateral sclerosis (ALS)
TDP-43
TDP-43 knock-in mice
Online Access:https://doi.org/10.1186/s13041-020-0550-4

Internet

https://doi.org/10.1186/s13041-020-0550-4

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