Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine

Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine

Abstract Background We previously showed that the autophagy inhibitor chloroquine (CQ) increases inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in sterile liver injury. However, the role of caspase-1/11 in the recovery of muscle from ischemia caused by perip...

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Bibliographic Details
Main Authors: Ulka Sachdev, Ricardo Ferrari, Xiangdong Cui, Abish Pius, Amrita Sahu, Michael Reynolds, Hong Liao, Ping Sun, Sunita Shinde, Fabrisia Ambrosio, Sruti Shiva, Patricia Loughran, Melanie Scott
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Medicine
Subjects:
Ischemic muscle
Inflammasome
Glycolysis
Oxidative phosphorylation
Lysosomal inhibition
Autophagy
Online Access:http://link.springer.com/article/10.1186/s10020-020-00190-2

Internet

http://link.springer.com/article/10.1186/s10020-020-00190-2

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