Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines

Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines

Chronic obstructive pulmonary disease (COPD) is a devastating, irreversible pathology affecting millions of people worldwide. Clinical studies show that currently available therapies are insufficient, have no or little effect on elevated comorbidities and on systemic inflammation. To develop alterna...

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Bibliographic Details
Main Authors: Diana Feller, Jozsef Kun, Istvan Ruzsics, Judit Rapp, Veronika Sarosi, Krisztian Kvell, Zsuzsanna Helyes, Judit E. Pongracz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
chronic obstructive pulmonary disease
Wnt5a
extracellular vesicles
peroxisome proliferator-activated receptor gamma
inflammatory cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01724/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01724/full

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