Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.

Fatigue is a predictor of cardiovascular events in patients with end-stage renal disease (ESRD) undergoing hemodialysis treatment. We hypothesized that multinutritional support would improve quality of life, fatigue symptoms, and potential quantitative measures including endocrine, immune and autono...

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Main Authors: Sanae Fukuda, Hidenori Koyama, Kazuhiro Kondo, Hisako Fujii, Yoshinobu Hirayama, Tsutomu Tabata, Mikio Okamura, Tomoyuki Yamakawa, Shigeki Okada, Sumio Hirata, Hiroshi Kiyama, Osami Kajimoto, Yasuyoshi Watanabe, Masaaki Inaba, Yoshiki Nishizawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4352065?pdf=render
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spelling doaj-800e6f099d2f4032b52b163ee2cca53b2020-11-24T21:32:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011957810.1371/journal.pone.0119578Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.Sanae FukudaHidenori KoyamaKazuhiro KondoHisako FujiiYoshinobu HirayamaTsutomu TabataMikio OkamuraTomoyuki YamakawaShigeki OkadaSumio HirataHiroshi KiyamaOsami KajimotoYasuyoshi WatanabeMasaaki InabaYoshiki NishizawaFatigue is a predictor of cardiovascular events in patients with end-stage renal disease (ESRD) undergoing hemodialysis treatment. We hypothesized that multinutritional support would improve quality of life, fatigue symptoms, and potential quantitative measures including endocrine, immune and autonomic functions in patients with ESRD undergoing hemodialysis.Two hundred and two hemodialysis patients were randomly assigned to receive active treatment (containing vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, vitamin C, carnitine, coenzyme Q10, naïve galacto-oligosaccharide, and zinc) or placebo after each dialysis session for 12 weeks. The patients and attending physicians were blinded to the treatment, and 172 patients (86 in each group) completed the study. Fatigue was evaluated via fatigue questionnaire at 0, 4, and 12 weeks. To assess human herpes virus (HHV) 6 and 7 reactivation, numbers of viral DNA copies were determined in saliva by polymerase chain reaction at weeks 0 and 12. Autonomic function was determined via measurement of beat-to-beat variation by using acceleration plethysmography.Clinical characteristics, changes in fatigue, quality of life score, endocrine functions, and laboratory data did not differ significantly between the two groups. Several parameters of heart rate variability significantly increased after nutritional treatment compared to placebo. Nutritional drink for 12 weeks significantly suppressed HHV7 DNA copy numbers. Similarly, HHV6 DNA copy numbers tended to be decreased by treatment but without reaching statistical significance.Nutritional supplementation may modulate immune and autonomic dysfunction in ESRD patients undergoing hemodialysis.http://europepmc.org/articles/PMC4352065?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Sanae Fukuda
Hidenori Koyama
Kazuhiro Kondo
Hisako Fujii
Yoshinobu Hirayama
Tsutomu Tabata
Mikio Okamura
Tomoyuki Yamakawa
Shigeki Okada
Sumio Hirata
Hiroshi Kiyama
Osami Kajimoto
Yasuyoshi Watanabe
Masaaki Inaba
Yoshiki Nishizawa
spellingShingle Sanae Fukuda
Hidenori Koyama
Kazuhiro Kondo
Hisako Fujii
Yoshinobu Hirayama
Tsutomu Tabata
Mikio Okamura
Tomoyuki Yamakawa
Shigeki Okada
Sumio Hirata
Hiroshi Kiyama
Osami Kajimoto
Yasuyoshi Watanabe
Masaaki Inaba
Yoshiki Nishizawa
Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
PLoS ONE
author_facet Sanae Fukuda
Hidenori Koyama
Kazuhiro Kondo
Hisako Fujii
Yoshinobu Hirayama
Tsutomu Tabata
Mikio Okamura
Tomoyuki Yamakawa
Shigeki Okada
Sumio Hirata
Hiroshi Kiyama
Osami Kajimoto
Yasuyoshi Watanabe
Masaaki Inaba
Yoshiki Nishizawa
author_sort Sanae Fukuda
title Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
title_short Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
title_full Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
title_fullStr Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
title_full_unstemmed Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
title_sort effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description Fatigue is a predictor of cardiovascular events in patients with end-stage renal disease (ESRD) undergoing hemodialysis treatment. We hypothesized that multinutritional support would improve quality of life, fatigue symptoms, and potential quantitative measures including endocrine, immune and autonomic functions in patients with ESRD undergoing hemodialysis.Two hundred and two hemodialysis patients were randomly assigned to receive active treatment (containing vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, vitamin C, carnitine, coenzyme Q10, naïve galacto-oligosaccharide, and zinc) or placebo after each dialysis session for 12 weeks. The patients and attending physicians were blinded to the treatment, and 172 patients (86 in each group) completed the study. Fatigue was evaluated via fatigue questionnaire at 0, 4, and 12 weeks. To assess human herpes virus (HHV) 6 and 7 reactivation, numbers of viral DNA copies were determined in saliva by polymerase chain reaction at weeks 0 and 12. Autonomic function was determined via measurement of beat-to-beat variation by using acceleration plethysmography.Clinical characteristics, changes in fatigue, quality of life score, endocrine functions, and laboratory data did not differ significantly between the two groups. Several parameters of heart rate variability significantly increased after nutritional treatment compared to placebo. Nutritional drink for 12 weeks significantly suppressed HHV7 DNA copy numbers. Similarly, HHV6 DNA copy numbers tended to be decreased by treatment but without reaching statistical significance.Nutritional supplementation may modulate immune and autonomic dysfunction in ESRD patients undergoing hemodialysis.
url http://europepmc.org/articles/PMC4352065?pdf=render
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