Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Abstract Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse model of PD, elicited retrograde trans-synaptic spreadi...

Full description

Bibliographic Details
Main Authors: Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Parkinson’s disease
Neuropathic pain
Nociception
Protein aggregation
Online Access:https://doi.org/10.1186/s40478-021-01131-8

Similar Items

Similar Items