Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

While retroviral DNA is synthesized normally after infection by integrase-deficient viruses, the resultant episomal DNA is then epigenetically silenced. Here, we show that expression of the Tax transcription factor encoded by a second human retrovirus, HTLV-1, prevents or reverses the epigenetic sil...

Full description

Bibliographic Details
Main Authors: Ishak D. Irwan, Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, Bryan R. Cullen
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
hiv-1
htlv-1
tax
integrase
cccdna
integrase inhibitors
epigenetic gene regulation
nf-κb
human t-cell leukemia virus
human immunodeficiency virus
Online Access:https://doi.org/10.1128/mBio.01038-20

Internet

https://doi.org/10.1128/mBio.01038-20

Similar Items